Digistain Nasıl Çalışır?
Digistain®, kanser tedavisi rehberliği için güvenilir ve kişiselleştirilmiş bir risk skoru sunmak amacıyla markörleri protein düzeyinde ölçen tescilli bir yöntem kullanarak biyolojik olarak aşağı akımda çalışmaktadır.
Digistain'in Arkasındaki Bilim
Digistain, tümör biyopsilerinin bileşimini analiz etmek ve kanserin yayılma olasılığını tahmin etmek için kızılötesi spektrometriyi kullanmaktadır. Infrared spectrometry is commonly used by chemists to deduce the chemical structure of large molecules. It is also used in various other fields of science and technology including chemical analysis, environmental monitoring, material characterisation, forensic analysis, and astronomical studies.
Kızılötesi Spektrometri Nasıl Çalışır?
Bir biyomolekülün farklı kimyasal grupları, kızılötesi ışığı çok spesifik dalga boylarında absorbe eder. As the light passes through or reflects off the sample, certain wavelengths are absorbed, while others pass through. This absorption creates a unique pattern, known as an infrared spectrum, which is a graph showing the amount of light absorbed at each wavelength.
The peaks on the spectrum represent wavelengths where absorption occurs, corresponding to specific vibrations of chemical bonds within the molecule. By analysing these peaks, scientists can identify the functional groups present in a biomolecule. This allows them to determine its molecular structure and composition by acting as a molecular “fingerprint”, enabling precise identification of the biomolecule based on its unique vibrational characteristics.
By analysing wavelengths that are known to be absorbed by nucleic acids and cell proteins. This imaging approach enables Digistain to measure chemical concentrations associated with tumour malignancy, precisely determine the characteristics of cancer cells and quantify validated pathology markers correlated to tumour proliferation.
Digistain Testi Nasıl Çalışır?
Kızılötesi spektrometri kullanarak Digistain, her biyopsiden benzersiz bir spektral imza yakalar ve Digistain İndeksini üretmek için biyopsi başına 10.000’den fazla veri noktasında analiz gerçekleştirir.
Using this data, Digistain’s proprietary artificial intelligence applies a multivariate model that integrates key clinicopathological factors, such as age, tumour grade, tumour size, and lymph node status. It then identifies risk profiling patterns and computes an accurate risk score – the Digistain Prognostic Score.
The report provides clinicians with a single-digit score predicting the proliferation risk of sample cancer cells to support adjuvant (post-surgery) chemotherapy decision-making.
Digistain's workflow-integrated platform has undergone rigorous clinical assessment, validating its ability to provide risk stratification information for breast cancer patients.
H&E Boyalı
DIGISTAIN® Optik Tarama
Soldaki görüntü geleneksel H&E boyama yaklaşımını göstermektedir; sağdaki görüntü ise daha yüksek hassasiyetli ölçüm için daha fazla tümör kontrastı ve detayı sağlayan Digistain yaklaşımını göstermektedir.. Image on the right shows Digistain approach with greater tumour contrast and detail enabling higher precision measurement
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